Hydrochloric Acid → [4-Chloro-6-(p-chlorobenzylamino)-2-pyrimidinylthio]acetic acid

反応式

C([O:3][C:4](=[O:23])[CH2:5][S:6][C:7]1[N:12]=[C:11]([Cl:13])[CH:10]=[C:9]([NH:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)[N:8]=1)C.[OH-].[Na+].Cl>>[Cl:13][C:11]1[CH:10]=[C:9]([NH:14][CH2:15][C:16]2[CH:17]=[CH:18][C:19]([Cl:22])=[CH:20][CH:21]=2)[N:8]=[C:7]([S:6][CH2:5][C:4]([OH:23])=[O:3])[N:12]=1

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 14798Sodium Hydroxide

HCID 53738869[4-Chloro-6-(p-chlorobenzylamino)-2-pyrimidinylthio]acetic acid ethyl ester

生成物 1

HCID 21557346[4-Chloro-6-(p-chlorobenzylamino)-2-pyrimidinylthio]acetic acid収率 77.2%

実験手順

[4-Chloro-6-(p-chlorobenzylamino)-2-pyrimidinylthio]acetic acid ethyl ester (1.4 g) was heated for 5 minutes with 30 ml. of 30% sodium hydroxide solution on a hot plate. The reaction mixture was then cooled and acidified with concentrated hydrochloric acid solution. The resulting precipitate was removed by filtration, washed with water and recrystallized from ethanol to afford 1.0 g of product, mp. 211°-213°C., decomp.