Potassium Permanganate → HCID 12898485、化合物

HRID 1579392ノート

反応式

HRID 1579392 の反応式
[CH3:1][CH:2]([CH3:20])[CH:3]([C:5]1[CH:6]=[CH:7][C:8]2[O:17][C:12]3=[N:13][CH:14]=[CH:15][CH:16]=[C:11]3[C:10](=[O:18])[C:9]=2[CH:19]=1)[OH:4].[Mn]([O-])(=O)(=O)=O.[K+]>CC(C)=O>[C:3]([C:5]1[CH:6]=[CH:7][C:8]2[O:17][C:12]3=[N:13][CH:14]=[CH:15][CH:16]=[C:11]3[C:10](=[O:18])[C:9]=2[CH:19]=1)(=[O:4])[CH:2]([CH3:20])[CH3:1]

参加物

4

反応物 2

HCID 516875Potassium PermanganateHCID 13207925HCID 13207925、化合物

生成物 1

HCID 12898485HCID 12898485、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 2.7 g of 2-methyl-1-(5-oxo-5H-[1]benzopyrano[2,3-b]pyridin-7-yl)-1-propanol, 60 ml of acetone and 1.5 g of potassium permanganate is refluxed for 6 hours. The reaction mixture is filtered, and the residue is washed thoroughly was chloroform. The filtrate and washings are concentrated, and the residue is purified by column chromatography on silica gel with chloroform as eluent, and further by recrystallization from ethanol to give 7-isobutyryl-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine melting at 155°-156°C.

後処理

  1. temperatureis refluxed for 6 hours
  2. filtrationThe reaction mixture is filtered
  3. washthe residue is washed thoroughly was chloroform
  4. concentrationThe filtrate and washings are concentrated
  5. customthe residue is purified by column chromatography on silica gel with chloroform as eluent
  6. customfurther by recrystallization from ethanol

出典と根拠

ORDレコード
ord-a725107989af4e2292a9931ddceeaf04
出典データセット
uspto-grants-1976_01
特許番号
US03931199

反応ノート

読み込み中…