Water → aluminum 2-(5H-[1]-benzopyrano[2,3-b]pyridin-7-yl)propionate

HRID 1579455

反応式

HRID 1579455 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]2[CH2:7][C:8]3[CH:14]=[C:13]([CH:15]([CH3:19])[C:16]([OH:18])=[O:17])[CH:12]=[CH:11][C:9]=3[O:10][C:2]=12.CC(C)[O-].[Al+3:24].CC(C)[O-].CC(C)[O-].O>C(O)(C)C>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]2[CH2:7][C:8]3[CH:14]=[C:13]([CH:15]([CH3:19])[C:16]([O-:18])=[O:17])[CH:12]=[CH:11][C:9]=3[O:10][C:2]=12.[Al+3:24].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]2[CH2:7][C:8]3[CH:14]=[C:13]([CH:15]([CH3:19])[C:16]([O-:18])=[O:17])[CH:12]=[CH:11][C:9]=3[O:10][C:2]=12.[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]2[CH2:7][C:8]3[CH:14]=[C:13]([CH:15]([CH3:19])[C:16]([O-:18])=[O:17])[CH:12]=[CH:11][C:9]=3[O:10][C:2]=12

参加物

5

反応物 3

HCID 962WaterHCID 4888PranoprofenHCID 11143Aluminum isopropoxide

生成物 1

HCID 21568497aluminum 2-(5H-[1]-benzopyrano[2,3-b]pyridin-7-yl)propionate

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒2 回

実験手順

2.5 G of 2-(5H-[1]benzopyrano[2,3-b]pyridin-7-yl)propionic acid is dissolved in 80 ml of isopropyl alcohol. A solution of 2.1 g of aluminum isopropoxide in 25 ml of isopropyl alcohol is added dropwise to the solution with stirring, white crystals being immediately yielded. After refluxing the mixture for 1 hour, 3 ml of water is added, and then the whole mixture is further refluxed for 1 hour. After cooling, the crystals are filtered off, washed with isopropyl alcohol, and dried to give aluminum 2-(5H-[1]-benzopyrano[2,3-b]pyridin-7-yl)propionate as white crystals melting at above 250°C.

後処理

  1. customwhite crystals being immediately yielded
  2. temperatureAfter refluxing the mixture for 1 hour
  3. temperaturethe whole mixture is further refluxed for 1 hour
  4. temperatureAfter cooling
  5. filtrationthe crystals are filtered off
  6. washwashed with isopropyl alcohol
  7. customdried

出典と根拠

ORDレコード
ord-046c44be7a3645999781925f225f62a5
出典データセット
uspto-grants-1976_01
特許番号
US03931205

関連ノート

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