1,3-Dibromopropane → 10-Phenyl-2,3,4,10-tetrahydropyrimido[1,2-a]indol-10-ol

HRID 1579527ノート

反応式

HRID 1579527 の反応式
[NH2:1][C:2]1[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)([OH:11])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.Br[CH2:19][CH2:20][CH2:21]Br>C(O)(C)C>[C:12]1([C:10]2([OH:11])[C:9]3[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=3[N:3]3[CH2:19][CH2:20][CH2:21][N:1]=[C:2]23)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

4

反応物 2

HCID 80011,3-DibromopropaneHCID 215687052-amino-3-phenyl-3H-indol-3-ol

生成物 1

HCID 1507593810-Phenyl-2,3,4,10-tetrahydropyrimido[1,2-a]indol-10-ol

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

2-Amino-3-phenyl-3H-indol-3-ol (2.24 g) was heated under reflux with isopropanol (20 ml) and 1,3-dibromopropane (2.0 g) for 20 hours. The reaction mixture was evaporated to 10 ml and diluted with a little ether. The title compound was obtained as its hydrobromide salt 0.73 g., m.p. 260°-262°C (decomp.) and could be recrystallized from methanol, ethanol or isopropanol with or without the addition of ethyl acetate or ether.

後処理

  1. customThe reaction mixture was evaporated to 10 ml
  2. additiondiluted with a little ether

出典と根拠

ORDレコード
ord-4d5a026f279c4f2688f8270abe7bd5c8
出典データセット
uspto-grants-1976_01
特許番号
US03931226

反応ノート

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