Sodium borohydride → HCID 53701734、化合物
反応式
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[O:15][C:14]([C:16]([CH3:18])=[O:17])=[CH:13][CH:12]=2)=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[BH4-].[Na+]>O1CCOCC1.O>[C:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]2[O:15][C:14]([CH:16]([OH:17])[CH3:18])=[CH:13][CH:12]=2)=[CH:9][CH:10]=1)(=[O:3])[CH3:2]参加物
4
実験手順
To a stirring mixture of 22 g (0.090 mole) of methyl 5-(p-acetamido-phenyl)-2-furyl ketone and 345 ml of 95% dioxane/H2O was added portionwise 3.4 g (0.090 mole) of NaBH4 while maintaining the temperature at 15°-20°. The resulting mixture was stirred overnight at room temperature and then added to ice/water. The solid was filtered and dried at 60° to yield 21 g (95%), m.p. 175°-177°, of title compound.
後処理
- temperaturewhile maintaining the temperature at 15°-20°
- filtrationThe solid was filtered
- customdried at 60°
- customto yield 21 g (95%), m.p. 175°-177°
出典と根拠
- ORDレコード
- ord-7bd0c69483d443ee9d0658c8fa0b05ee
- 出典データセット
- uspto-grants-1976_01
- 特許番号
- US03931247
反応ノート
読み込み中…