Sodium Hydroxide → HCID 21569669、化合物

HRID 1579849ノート

反応式

HRID 1579849 の反応式
[CH2:1]([O:3][C:4]1[CH2:8][CH2:7][C:6](=[O:9])[C:5]=1[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([O:18]CC)=[O:17])[CH3:2].[OH-].[Na+]>C(O)C>[CH2:1]([O:3][C:4]1[CH2:8][CH2:7][C:6](=[O:9])[C:5]=1[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])[CH3:2]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 21569671HCID 21569671、化合物

生成物 1

HCID 21569669HCID 21569669、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture containing 22.16 parts of ethyl 2-ethoxy-5-oxocyclopent 1-eneheptanoate, 785 parts of 0.1N aqueous sodium hydroxide and 320 parts of ethanol is stored at room temperature for about 48 hours, then is concentrated to approximately 2/3 volume by distillation under reduced pressure. The residual solution is washed with ether, acidified with dilute hydrochloric acid, then extracted with ethyl acetate. The ethyl acetate extracts are washed with water, dried over anhydrous magnesium sulfate and evaporated to dryness by distillation under reduced pressure. The residual solid residue is purified by recrystallization from ether-benzene to afford 2-ethoxy-5-oxocyclopent-1-eneheptanoic acid, melting at about 65°-66°.

後処理

  1. concentrationis concentrated to approximately 2/3 volume by distillation under reduced pressure
  2. washThe residual solution is washed with ether
  3. extractionextracted with ethyl acetate
  4. washThe ethyl acetate extracts are washed with water
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customevaporated to dryness by distillation under reduced pressure
  7. customThe residual solid residue is purified by recrystallization from ether-benzene

出典と根拠

ORDレコード
ord-200d7c0a933e44f7959e1bed07694867
出典データセット
uspto-grants-1976_01
特許番号
US03931411

反応ノート

読み込み中…