Benzene → Ethyl 5-methyl-2-phenylimidazole-4-acetate

HRID 1580096ノート

反応式

HRID 1580096 の反応式
[CH3:1][C:2]1[NH:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:13][C:14]([OH:16])=[O:15].[CH2:17](O)[CH3:18].C1(C)C=CC(S(O)(=O)=O)=CC=1.C1C=CC=CC=1>O>[CH3:1][C:2]1[NH:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15]

参加物

6

反応物 4

HCID 241BenzeneHCID 702EthanolHCID 6101p-Toluenesulfonic acidHCID 215650655-Methyl-2-phenylimidazole-4-acetic acid

生成物 1

HCID 22597552Ethyl 5-methyl-2-phenylimidazole-4-acetate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

About 40 g of 5-methyl-2-phenylimidazole-4-acetic acid, 100 ml of absolute ethanol, 1 g of p-toluenesulfonic acid and 650 ml of benzene is heated under reflux with azeotropic removal of water overnight (about 15 hours). The reaction mixture is filtered, washed with sodium bicarbonate solution, dried over anhydrous magnesium sulfate and the solvent evaporated in vacuo to yield the product, ethyl 5-methyl-2-phenylimidazole-4-acetate.

後処理

  1. filtrationThe reaction mixture is filtered
  2. washwashed with sodium bicarbonate solution
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customthe solvent evaporated in vacuo

出典と根拠

ORDレコード
ord-704dcf766cc24e3e82f991e7e055e8d0
出典データセット
uspto-grants-1976_01
特許番号
US03932445

反応ノート

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