Hydrochloric Acid → Mls003115290

HRID 1580155ノート

反応式

HRID 1580155 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]=[C:8]2[CH2:17][CH2:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]2=[O:18])=[CH:3][CH:2]=1.C(Cl)(Cl)Cl.[OH:23]O.Cl>O.C(O)C>[N:1]1[CH:6]=[CH:5][C:4]([CH:7]2[O:23][C:8]32[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]3=[O:18])=[CH:3][CH:2]=1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 784Hydrogen PeroxideHCID 6212ChloroformHCID 27327162-(Pyridin-4-ylmethylidene)-3,4-dihydronaphthalen-1-one

生成物 1

HCID 317204Mls003115290

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒2 回

実験手順

To a mixture of 10 g. of 2-(4-pyridylmethylene)-3,4-dihydro-1(2H)-naphthalenone in 100 ml of water and 200 ml of ethanol is added sufficient chloroform to dissolve the reactants. The pH is adjusted to between 7 and 9 and a 3 molar excess of 30% hydrogen peroxide in water is added dropwise at room temperature. The reactants are stirred for 5 hours after which sufficient ferrous sulfate is added to neutralize the excess peroxide. The mixture is then acidified with hydrochloric acid and the organic solvent evaporated off. The water solution remaining is made basic and extracted with chloroform. The chloroform is evaporated off yielding 3'-(4-pyridyl)-spiro[1,2,3,4-tetrahydronaphthalene-2,2'-oxirane]-1-one.

後処理

  1. additionTo a mixture of 10 g
  2. dissolutionto dissolve the reactants
  3. additionis added
  4. customthe organic solvent evaporated off
  5. extractionextracted with chloroform
  6. customThe chloroform is evaporated off

出典と根拠

ORDレコード
ord-45e33bef9cce45a896b4ce25722ebd81
出典データセット
uspto-grants-1976_01
特許番号
US03932430

反応ノート

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