N-[2-(5-nitro-1H-indol-3-yl)ethyl]acetamide → N-[2-(5-Amino-1H-indol-3-yl)ethyl]acetamide
反応式
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][CH:8]=[C:7]2[CH2:13][CH2:14][NH:15][C:16](=[O:18])[CH3:17])([O-])=O>[Pd].C(O)C>[NH2:1][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][CH:8]=[C:7]2[CH2:13][CH2:14][NH:15][C:16](=[O:18])[CH3:17]参加物
4
実験手順
The product from Example 2 (0.05 mmol) is taken into ethanol (3 mL) and hydrogenated 6 h at 3 atmospheres of H2 pressure over a catalytic amount of 10% Pd/C. The catalyst is removed by filtration through Celite and the solvent removed in vacuo, affording the title compound. This product is somewhat air sensitive and is used immediately for subsequent reactions.
後処理
- customThe catalyst is removed by filtration through Celite
- customthe solvent removed in vacuo
出典と根拠
- ORDレコード
- ord-3d06ed28c8df4b51a5d3ea72070d9562
- 出典データセット
- uspto-grants-2004_05
- 特許番号
- US06730707B2
反応ノート
読み込み中…