(R)-(-)-3-chloromethylsulfinyl-7-fluoro-1-methyl-4-quinolone → 3-Chloromethylthio-7-fluoro-1-methyl-4-quinolone

HRID 1581766

反応式

HRID 1581766 の反応式
[Cl:1][CH2:2][S@:3]([C:5]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][C:10]([F:16])=[CH:11][CH:12]=2)[N:7]([CH3:17])[CH:6]=1)=O.ClC[S@@](C1C(=O)C2C(=CC(F)=CC=2)N(C)C=1)=O.FC1C=C2C(C(=S)C(C)=CN2C)=CC=1>>[Cl:1][CH2:2][S:3][C:5]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][C:10]([F:16])=[CH:11][CH:12]=2)[N:7]([CH3:17])[CH:6]=1

参加物

4

反応物 3

HCID 10445996(R)-(-)-3-chloromethylsulfinyl-7-fluoro-1-methyl-4-quinoloneHCID 10445997(S)-(+)-3-chloromethylsulfinyl-7-fluoro-1-methyl-4-quinoloneHCID 865891517-Fluoro-1-methyl-3-methylthio-4-quinolone

生成物 1

HCID 104452083-Chloromethylthio-7-fluoro-1-methyl-4-quinolone

実験手順

FIG. 9 depicts the second step in the synthesis of e.e.(S)-(+)-3-chloromethylsulfinyl-7-fluoro-1-methyl-4-quinolone and (R)-(−)-3-chloromethylsulfinyl-7-fluoro-1-methyl-4-quinolone. In this step, 7-fluoro-1-methyl-3-methylthio-4-quinolone is chlorinated as described to produce 3-chloromethylthio-7-fluoro-1-methyl-4-quinolone.

後処理

  1. customin the synthesis of e.e

出典と根拠

ORDレコード
ord-ba704b18a28a44fc8338f68904a66385
出典データセット
uspto-grants-2004_05
特許番号
US06730790B2

関連ノート

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