Hydrazine hydrate (1:1) → 4-(2-Methoxyphenyl)-1H-pyrazole
反応式
C[N:2](C)[CH:3]=[C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[O:13][CH3:14])[CH:5]=O.O.[NH2:17]N>C(O)C>[CH3:14][O:13][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=1[C:4]1[CH:3]=[N:2][NH:17][CH:5]=1参加物
4
実験手順
A solution of 3-dimethylamino-2-(2-methoxyphenyl)propenal (4.68 g, 22.8 mmol) and hydrazine hydrate (6.7 ml) in ethanol (100 ml) is heated at reflux for 30 minutes. The solvent is removed in vacuo and the residue is chromatographed (silica gel, dichloromethane/ethanol 95:5) to give 2.69 g of 4-(2-methoxyphenyl)pyrazole (68%).
後処理
- temperatureat reflux for 30 minutes
- customThe solvent is removed in vacuo
- customthe residue is chromatographed (silica gel, dichloromethane/ethanol 95:5)
出典と根拠
- ORDレコード
- ord-5eed3c7b1660419eb4b7d03afb07a3e3
- 出典データセット
- uspto-grants-2004_05
- 特許番号
- US06730792B2
反応ノート
読み込み中…