Nitronium tetrafluoroborate → 2-Bromo-3,4-dimethoxy-6-nitrobenzonitrile

HRID 1582383ノート

反応式

HRID 1582383 の反応式
[Br:1][C:2]1[C:9]([O:10][CH3:11])=[C:8]([O:12][CH3:13])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].F[B-](F)(F)F.[O:19]=[N+:20]=[O:21]>C(#N)C>[Br:1][C:2]1[C:9]([O:10][CH3:11])=[C:8]([O:12][CH3:13])[CH:7]=[C:6]([N+:20]([O-:21])=[O:19])[C:3]=1[C:4]#[N:5]

参加物

4

反応物 2

HCID 11073463Nitronium tetrafluoroborateHCID 227212152-Bromo-3,4-dimethoxybenzonitrile

生成物 1

HCID 227212172-Bromo-3,4-dimethoxy-6-nitrobenzonitrile収率 85.3%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a stirred solution of 2-bromo-3,4-dimethoxybenzonitrile (prepared according to step (b), 5.77 g, 23.8 mmol) in acetonitrile (58 ml) at 0° C. was added nitronium tetrafluoroborate (5.67 g, 42.9 mmol) portionwise ensuring that the temperature did not rise above 10° C. After stirring for 4 hours in the range 0° C. to 10° C., the reaction was cautiously quenched into 10% aqueous NaHCO3 (66 ml). The resulting suspension was filtered and the solid dried in vacuo overnight to give 5.83 g of the subtitle product (85%).

後処理

  1. customdid not rise above 10° C
  2. customthe reaction was cautiously quenched into 10% aqueous NaHCO3 (66 ml)
  3. filtrationThe resulting suspension was filtered
  4. customthe solid dried in vacuo overnight

出典と根拠

ORDレコード
ord-684d5a538104404fb9da1cdd817793cb
出典データセット
uspto-grants-2004_05
特許番号
US06734303B2

反応ノート

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