Formic Acid → HCID 136347718、化合物

HRID 1582429ノート

反応式

HRID 1582429 の反応式
C([O:8][C@H:9]1[C@H:13]2[O:14][CH2:15][C@:10]1([CH2:32][OH:33])[O:11][C@H:12]2[N:16]1[CH:24]=[N:23][C:22]2[C:21](=[O:25])[NH:20][C:19]([NH:26][C:27](=[O:31])[CH:28]([CH3:30])[CH3:29])=[N:18][C:17]1=2)C1C=CC=CC=1.C(O)=O>CO.[Pd]>[OH:8][C@H:9]1[C@H:13]2[O:14][CH2:15][C@:10]1([CH2:32][OH:33])[O:11][C@H:12]2[N:16]1[CH:24]=[N:23][C:22]2[C:21](=[O:25])[NH:20][C:19]([NH:26][C:27](=[O:31])[CH:28]([CH3:29])[CH3:30])=[N:18][C:17]1=2

参加物

5

反応物 2

HCID 284Formic AcidHCID 135405285HCID 135405285、化合物

生成物 1

HCID 136347718HCID 136347718、化合物収率 98.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of compound 15 (5.8 g, 12.7 mmol) in methanol (50 mL) was added 10% Pd/C (2 g) and formic acid (3 mL). The mixture was refluxed for 5 h, cooled to ambient temperature and filtrated through silica gel column. The column was washed with methanol (50 mL), all the filtrate was concentrated under reduced pressure to yield 4.55 g (98%) of compound 16 as a glass-like solid.

後処理

  1. temperatureThe mixture was refluxed for 5 h
  2. filtrationfiltrated through silica gel column
  3. washThe column was washed with methanol (50 mL), all the filtrate
  4. concentrationwas concentrated under reduced pressure

出典と根拠

ORDレコード
ord-155de6c7751749e09a730009ea9c5cd3
出典データセット
uspto-grants-2004_05
特許番号
US06734291B2

反応ノート

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