Ethyl bromoacetate → Acetic acid, 2-(4-cyanophenoxy)-, ethyl ester

反応式

[CH2:1]([O:3][C:4](=[O:37])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2N(C(=O)C(C)C)C(C3C=CC(Cl)=CC=3)C(C3C=CC(Cl)=CC=3)[N:17]=2)=[CH:9][CH:8]=1)[CH3:2].OC1C=CC(C#N)=CC=1.BrCC(OCC)=O>>[C:13]([C:10]1[CH:11]=[CH:12][C:7]([O:6][CH2:5][C:4]([O:3][CH2:1][CH3:2])=[O:37])=[CH:8][CH:9]=1)#[N:17]

参加物

反応物 3

HCID 7748Ethyl bromoacetate

HCID 130194-Cyanophenol

HCID 66979134{4-[4,5-Bis-(4-chloro-phenyl)-1-isobutyryl-4,5-dihydro-1H-imidazol-2-yl]-phenoxy}-acetic acid ethyl ester

生成物 1

HCID 207426Acetic acid, 2-(4-cyanophenoxy)-, ethyl ester

実験手順

{4-[4,5-Bis-(4-chloro-phenyl)-1-isobutyryl-4,5-dihydro-1H-imidazol-2-yl]-phenoxy}-acetic acid ethyl ester. HR-MS (ES, m/z) calculated for C29H29N2O4Cl2[(M+H)+]539.1499, observed 539.1506. The starting ethyl (4-cyano-phenoxy)-acetate was prepared from 4-hydroxy-benzonitrile and ethyl bromoacetate as described in Kirkiacharian, S.; Goma, J. R. et al. Ann. Pharm. Fr. 1989, 47, 16-23.

出典と根拠

ORDレコード: ord-1dbeed72a6f54eeab918223addd0d4a6
出典データセット: uspto-grants-2004_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06734302B2

反応ノート

読み込み中…

参加物