Trifluoroacetic acid → HCID 69929667、化合物

HRID 1582741ノート

反応式

HRID 1582741 の反応式
C(O[C:6](=O)[N:7]([C@H:9]([C:25](=[O:38])[NH:26][CH2:27][C:28]1([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH2:31][CH2:30][CH2:29]1)[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:13][CH:12]=1)C)(C)(C)C.[C:40]([OH:46])([C:42]([F:45])([F:44])[F:43])=[O:41]>C(Cl)Cl>[F:43][C:42]([F:45])([F:44])[C:40]([OH:46])=[O:41].[CH2:18]([O:17][C:14]1[CH:15]=[CH:16][C:11]([CH2:10][C@H:9]([NH:7][CH3:6])[C:25]([NH:26][CH2:27][C:28]2([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[CH2:29][CH2:30][CH2:31]2)=[O:38])=[CH:12][CH:13]=1)[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 69927875HCID 69927875、化合物

生成物 1

HCID 69929667HCID 69929667、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of (S)-{2-(4-Benzyloxy-phenyl)-1-[(1-phenyl-cyclobutylmethyl)-carbamoyl]-ethyl}-methyl-carbamic acid tert-butyl ester (from Step 1; 1.07 g, 2.02 mmol) in methylene chloride (10 mL) was added TFA (2.5 mL). The solution was stirred at room temperature for 2 hours and then concentrated in vacuo. Coevaporisation with methylene chloride was carried out twice to give the desired product which was used without further purification.

後処理

  1. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-6400e92f43bb4cb3a24dfc812ceaf6e6
出典データセット
uspto-grants-2004_05
特許番号
US06737410B1

反応ノート

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