Ethanol → 5-Nitro-1-tetralone oxime

HRID 1582781

反応式

HRID 1582781 の反応式
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH2:6][CH2:7][CH2:8][C:9]2=O)([O-:3])=[O:2].C(O)C.Cl.[NH2:19][OH:20]>O>[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH2:6][CH2:7][CH2:8][C:9]2=[N:19][OH:20])([O-:3])=[O:2]

参加物

5

反応物 3

HCID 702EthanolHCID 443297Hydroxyamine hydrochlorideHCID 102619465-Nitro-3,4-dihydronaphthalen-1(2H)-one

生成物 1

HCID 729651715-Nitro-1-tetralone oxime収率 90.3%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

In a 100 mL flask equipped with a reflux condenser were placed 2.26 g of 5-nitro-1-tetralone and 60 mL of ethanol. To the mixture was added a solution of hydroxylamine hydrochloride (1.82 g) in water (4.5 mL). The content of the flask was stirred with a stirring bar at reflux for 8 hours. After evaporating the solvent, the residue was purified by column chromatography (eluent: hexane/ethyl acetate=5/1)′ to give 2.2 g of 5-nitro-1-tetralone oxime.

後処理

  1. customIn a 100 mL flask equipped with a reflux condenser
  2. temperatureat reflux for 8 hours
  3. customAfter evaporating the solvent
  4. customthe residue was purified by column chromatography (eluent: hexane/ethyl acetate=5/1)′

出典と根拠

ORDレコード
ord-8b6e3766710e4df5bfa902d7d9ed712c
出典データセット
uspto-grants-2004_05
特許番号
US06737548B2

関連ノート

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