Methyl iodide → Methyl 2-[4-(3-chlorophenyl)-1-ethyl-7-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl]benzoate

HRID 1582957

反応式

HRID 1582957 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][CH:19]=1)[C:5]([C:7]1[C:8]([NH:14][CH2:15][CH3:16])=[N:9][C:10]([CH3:13])=[CH:11][CH:12]=1)=O.[C:20]1(=[O:31])[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:23][C:22](=[O:30])[O:21]1.CI.[C:34](=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[Cl:1][C:2]1[CH:3]=[C:4]([C:5]2[C:7]3[C:8](=[N:9][C:10]([CH3:13])=[CH:11][CH:12]=3)[N:14]([CH2:15][CH3:16])[C:22](=[O:30])[C:23]=2[C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][C:29]=2[C:20]([O:21][CH3:34])=[O:31])[CH:17]=[CH:18][CH:19]=1

参加物

6

反応物 4

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 12801Homophthalic anhydrideHCID 110549023-(3-Chlorobenzoyl)-2-ethylamino-6-methylpyridine

生成物 1

HCID 12991197Methyl 2-[4-(3-chlorophenyl)-1-ethyl-7-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl]benzoate

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

実験手順

After the reaction of 3-(3-chlorobenzoyl)-2-ethylamino-6-methylpyridine with isochroman-1,3-dione (75%) under heating, the compound obtained by usual work-up was reacted with methyl iodide in 2-butanone in the presence of potassium carbonate. Thereafter, the reaction mixture was worked up and purified in a usual manner to obtain methyl 2-[4-(3-chlorophenyl)-1-ethyl-7-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl]benzoate as a yellow solid. MS: 433.

後処理

  1. temperatureunder heating
  2. customthe compound obtained by usual work-up
  3. custompurified in a usual manner

出典と根拠

ORDレコード
ord-a612e152cc634790bb966fa1e53ed09b
出典データセット
uspto-grants-2004_05
特許番号
US06740662B1

関連ノート

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