Hydrazine hydrate (1:1) → 4,5-dihydro-6-(4-(imidazol-1-yl)phenyl)-5-methyl-3(2H)-pyridazinone

HRID 1583287ノート

反応式

HRID 1583287 の反応式
[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([C:12](=O)[CH:13]([CH3:18])[CH2:14][C:15](O)=[O:16])=[CH:8][CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.O.[NH2:21][NH2:22]>O>[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([C:12]3[CH:13]([CH3:18])[CH2:14][C:15](=[O:16])[NH:21][N:22]=3)=[CH:8][CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 13233878HCID 13233878、化合物

生成物 1

HCID 30217294,5-dihydro-6-(4-(imidazol-1-yl)phenyl)-5-methyl-3(2H)-pyridazinone

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

4-[4-(1-Imidazolyl)phenyl]-3-methyl-4-oxobutyric acid (75.7 g) was suspended in 145 m of water. After the addition of 17 ml of hydrazine hydrate, the reaction mixture was stirred at reflux temperature for 2 hours. After cooling, the precipitated solid was collected by filtration, washed with water, and dried.

後処理

  1. temperatureat reflux temperature for 2 hours
  2. temperatureAfter cooling
  3. filtrationthe precipitated solid was collected by filtration
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-d3f2d756278c4a09904fb12c29d79b79
出典データセット
uspto-grants-1985_11
特許番号
US04551455

反応ノート

読み込み中…