Sodium Hydroxide → 7-(Pyridin-3-yl)heptan-1-amine

HRID 1583422ノート

反応式

HRID 1583422 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14]C(=O)C)[CH:2]=1.[OH-].[Na+]>Cl>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH2:14])[CH:2]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 13557529N-[7-(Pyridin-3-yl)heptyl]acetamide

生成物 1

HCID 135575307-(Pyridin-3-yl)heptan-1-amine収率 81.2%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

A solution of 5.1 g of N-[7-(3-pyridyl)heptyl]acetamide was heated to reflux in diluted hydrochloric acid overnight. The mixture was cooled, made basic with 50% sodium hydroxide solution and was extracted with dichloromethane. The combined organic layers were dried over potassium carbonate and were evaporated. The residue was distilled to give 3.4 g of 3-pyridine heptanamine, bp 175°-180° C./0.4 mm.

後処理

  1. temperatureThe mixture was cooled
  2. extractionwas extracted with dichloromethane
  3. dry with materialThe combined organic layers were dried over potassium carbonate
  4. customwere evaporated
  5. distillationThe residue was distilled

出典と根拠

ORDレコード
ord-3805197ade654298a29bb3b30b38035f
出典データセット
uspto-grants-1985_11
特許番号
US04551460

反応ノート

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