Hydrazine hydrate (1:1) → 6-(Quinolin-3-yl)hexan-1-amine

HRID 1583436ノート

反応式

HRID 1583436 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][N:17]2C(=O)C3C(=CC=CC=3)C2=O)[CH:2]=1.O.NN>C(O)C>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH2:17])[CH:2]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 135575552-[6-(Quinolin-3-yl)hexyl]-1H-isoindole-1,3(2H)-dione

生成物 1

HCID 135575486-(Quinolin-3-yl)hexan-1-amine収率 89.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

3-Quinolinehexanamine was prepared in the same manner as described in Example 110, starting from 4.4 g of 2-[6-(3-quinolinyl)hexyl]-1H-isoindole-1,3(2H)-dione and 2.5 g of hydrazine hydrate in 60 ml of ethanol. The crude product was evaporatively distilled to give 2.5 g (89%) of 3-quinolinehexanamine, bp 144°-155° C./0.1 mm. Bis picrate mp 225°-226° C.

後処理

  1. custom3-Quinolinehexanamine was prepared in the same manner
  2. distillationThe crude product was evaporatively distilled

出典と根拠

ORDレコード
ord-21745a1fab1441a99373208ceaf63d74
出典データセット
uspto-grants-1985_11
特許番号
US04551460

反応ノート

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