3-Chloro-4-methylphenyl isocyanate → 4-Bromomethyl-3-chlorophenylisocyanate

HRID 1583483ノート

反応式

HRID 1583483 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]=[C:10]=[O:11])[CH:5]=[CH:6][C:7]=1[CH3:8].[Br:12]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>[Br:12][CH2:8][C:7]1[CH:6]=[CH:5][C:4]([N:9]=[C:10]=[O:11])=[CH:3][C:2]=1[Cl:1]

参加物

5

反応物 2

HCID 628323-Chloro-4-methylphenyl isocyanateHCID 67184N-bromobutanimide

生成物 1

HCID 135572724-Bromomethyl-3-chlorophenylisocyanate収率 100%

試薬・触媒・溶媒 2

HCID 7187Benzoyl Peroxide触媒HCID 5943Carbon Tetrachloride溶媒

実験手順

To a stirred solution of 100.0 grams (0.597 mole) of 3-chloro-4-methylphenylisocyanate in 1000 ml of carbon tetrachloride, under an argon atmosphere were added 116.8 grams (0.656 mole) of N-bromosuccinimide and 5.0 grams (0.021 mole) of benzoyl peroxide. The reaction mixture was warmed to reflux where it stirred for 4 hours; then it was allowed to cool to ambient temperature as it stood for 16 hours. The mixture was filtered and the filtrate concentrated under reduced pressure to give 147.1 grams of 4-bromomethyl-3-chlorophenylisocyanate as a residual oil. The oil was used without further purification.

後処理

  1. temperatureThe reaction mixture was warmed
  2. temperatureto reflux where it
  3. waitstood for 16 hours
  4. filtrationThe mixture was filtered
  5. concentrationthe filtrate concentrated under reduced pressure

出典と根拠

ORDレコード
ord-57883c279b6642189f7f2c9595aa8581
出典データセット
uspto-grants-1985_11
特許番号
US04552585

反応ノート

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