Iodoethane → HCID 18600216、化合物

HRID 1583568

反応式

HRID 1583568 の反応式
[CH3:1][C@H:2]([N:6]1CCC[C:7]1=[O:11])[C:3]([OH:5])=[O:4].C(I)C.[CH2:15]([S:22]CBr)[C:16]1[CH:21]=[CH:20]C=[CH:18][CH:17]=1>>[CH2:21]([C:16]1([CH2:15][SH:22])[CH2:17][CH2:18][N:6]([C@@H:2]([CH3:1])[C:3]([OH:5])=[O:4])[C:7]1=[O:11])[CH3:20]

参加物

4

反応物 3

HCID 6340IodoethaneHCID 4067177BenzylthiobromomethaneHCID 7175678(S)-2-(2-oxopyrrolidin-1-yl)propanoic acid

生成物 1

HCID 18600216HCID 18600216、化合物

実験手順

Following the procedures of Examples 1C-1E, α(S)-methyl-2-oxo-1-pyrrolidineacetic acid was first alkylated with ethyl iodide and then with benzylmercaptomethyl bromide. Removal of the benzyl group in the usual way and purification by chromatography provided the title compound as a mixture of diastereomers. [α]D25 =-4.04° (c=1, methanol).

後処理

  1. customRemoval of the benzyl group
  2. customin the usual way and purification by chromatography

出典と根拠

ORDレコード
ord-f5282b269af4496fb176721b5249d416
出典データセット
uspto-grants-1985_11
特許番号
US04552889

関連ノート

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