Water → (4-(2-Fluoroethoxy)phenyl)methanol

HRID 1583582ノート

反応式

HRID 1583582 の反応式
[F:1][CH2:2][CH2:3][O:4][C:5]1[CH:12]=[CH:11][C:8]([CH:9]=[O:10])=[CH:7][CH:6]=1.[BH4-].[Na+].O>C(O)C>[F:1][CH2:2][CH2:3][O:4][C:5]1[CH:12]=[CH:11][C:8]([CH2:9][OH:10])=[CH:7][CH:6]=1

参加物

5

反応物 3

HCID 962WaterHCID 4311764Sodium borohydride2 回HCID 150586494-(2-Fluoroethoxy)benzaldehyde

生成物 1

HCID 13367643(4-(2-Fluoroethoxy)phenyl)methanol収率 89.9%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

The crude 4-(2-fluoroethoxy)benzaldehyde (35.6 g) was dissolved in 140 ml of ethanol, and 11.0 g of sodium borohydride was carefully added to the solution at 47° to 50° C. After adding sodium borohydride, the reaction was carried out at 50° C. for 2 hours. After the reaction, the reaction mixture was cooled to room temperature and water was added. The mixture was extracted with toluene. The toluene layer was washed with water and dried over anhydrous sodium sulfate. Toluene was evaporated under reduced pressure to give 32.4 g of 4-(2-fluoroethoxy)benzyl alcohol as crystals (m.p. 37.3°-38.0° C.).

後処理

  1. customAfter the reaction
  2. extractionThe mixture was extracted with toluene
  3. washThe toluene layer was washed with water
  4. dry with materialdried over anhydrous sodium sulfate
  5. customToluene was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-346c693605af4bd19f5fe687b931aa98
出典データセット
uspto-grants-1985_11
特許番号
US04552894

反応ノート

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