Dimethylformamide → 4-(2-Fluoroethoxy)isopropenylbenzene

HRID 1583585

反応式

HRID 1583585 の反応式
CN(C)C=O.[C:6]([C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=1)([CH3:8])=[CH2:7].[F:16][CH2:17][CH2:18]Cl.C(=O)([O-])[O-].[K+].[K+]>O>[F:16][CH2:17][CH2:18][O:15][C:12]1[CH:13]=[CH:14][C:9]([C:6]([CH3:8])=[CH2:7])=[CH:10][CH:11]=1

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 129831-Chloro-2-fluoroethaneHCID 584247p-Isopropenylphenol

生成物 1

HCID 202592654-(2-Fluoroethoxy)isopropenylbenzene収率 95.7%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To 30 ml of dimethylformamide were added 7.0 g of 4-isopropenylphenol, 6.1 g of 1-fluoro-2-chloroethane and 8.7 g of potassium carbonate. With stirring, they were reacted at 120° C. for 4 hours. The reaction mixture was cooled to room temperature, and poured into water. The mixture was then extracted with toluene. The toluene layer was washed with water and dried over anhydrous sodium sulfate. Toluene was evaporated under reduced pressure to give 9.0 g of crude 4-(2-fluoroethoxy)isopropenylbenzene.

後処理

  1. customthey were reacted at 120° C. for 4 hours
  2. extractionThe mixture was then extracted with toluene
  3. washThe toluene layer was washed with water
  4. dry with materialdried over anhydrous sodium sulfate
  5. customToluene was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-c8440b73d64141fe9a53354cfa7b5462
出典データセット
uspto-grants-1985_11
特許番号
US04552894

関連ノート

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