Water → HCID 13535661、化合物

HRID 1583590ノート

反応式

HRID 1583590 の反応式
[F:1][CH2:2][CH2:3][O:4][C:5]1[CH:12]=[CH:11][C:8]([CH2:9]Cl)=[CH:7][CH:6]=1.[Cl:13][C:14]1[CH:25]=[CH:24][C:17]([O:18][C:19]([CH3:23])([CH3:22])[CH2:20][OH:21])=[CH:16][CH:15]=1.[OH-].[Na+].O>[Br-].C([N+](CC)(CC)CC1C=CC=CC=1)C.C1(C)C=CC=CC=1>[Cl:13][C:14]1[CH:25]=[CH:24][C:17]([O:18][C:19]([CH3:22])([CH3:23])[CH2:20][O:21][CH2:9][C:8]2[CH:11]=[CH:12][C:5]([O:4][CH2:3][CH2:2][F:1])=[CH:6][CH:7]=2)=[CH:16][CH:15]=1

参加物

7

反応物 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 191086602-(4-Chlorophenoxy)-2-methylpropan-1-olHCID 202592671-(Chloromethyl)-4-(2-fluoroethoxy)benzene

生成物 1

HCID 13535661HCID 13535661、化合物収率 91%

試薬・触媒・溶媒 2

HCID 165294Benzyltriethylammonium bromide触媒HCID 1140Toluene溶媒

反応条件

温度
50 °C

実験手順

A mixture consisting of 1.0 g of 4-(2-fluoroethoxy)benzyl chloride, 1.0 g of 2-(4-chlorophenoxy)-2-methylpropyl alcohol, 0.3 g of triethylbenzylammonium bromide and 20 g of a 50% aqueous solution of sodium hydroxide was stirred at 50° C. for 2 hours. The reaction mixture was cooled to room temperature, and poured into water. Toluene was added, and the mixture was fully stirred. The toluene layer was separated, washed with water, and dried over anhydrous sodium sulfate. Toluene and low-volatile components were evaporated under reduced pressure to give 1.6 g of the desired 4-(2-fluoroethoxy)benzyl 2-(4-chlorophenoxy)-2-methylpropyl ether.

後処理

  1. temperatureThe reaction mixture was cooled to room temperature
  2. stirringthe mixture was fully stirred
  3. customThe toluene layer was separated
  4. washwashed with water
  5. dry with materialdried over anhydrous sodium sulfate
  6. customToluene and low-volatile components were evaporated under reduced pressure

出典と根拠

ORDレコード
ord-9eefc2268fd841b5bb7506413bc17f9e
出典データセット
uspto-grants-1985_11
特許番号
US04552894

反応ノート

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