Sodium Hydroxide → 3-Acetyl-2-[2-[3-(carboxy)propoxy]phenyl]benzothiazoline

HRID 1583665ノート

反応式

HRID 1583665 の反応式
[C:1]([N:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[S:6][CH:5]1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][CH2:20][CH2:21][CH2:22][C:23]([O:25]CC)=[O:24])(=[O:3])[CH3:2].[OH-].[Na+]>CO>[C:1]([N:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[S:6][CH:5]1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][CH2:20][CH2:21][CH2:22][C:23]([OH:25])=[O:24])(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 135642173-Acetyl-2-[2-[3-(ethoxycarbonyl)-propoxy]phenyl]benzothiazoline

生成物 1

HCID 133359003-Acetyl-2-[2-[3-(carboxy)propoxy]phenyl]benzothiazoline収率 80%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To the solution of 7.71 g of 3-acetyl-2-[2-[3-(ethoxycarbonyl)propoxy]phenyl]benzothiazoline in 50 ml of methanol, 2N-sodium hydroxide solution is added and the reaction mixture is stirred for 2 hours at room temperature. Methanol is removed off in vacuo. The residue is acidified with 2N-hydrochloric acid to give 5.72 g (80%) of the titled compound.

後処理

  1. customMethanol is removed off in vacuo

出典と根拠

ORDレコード
ord-eb417c302c6f49fcb17faa8f44a40746
出典データセット
uspto-grants-1985_11
特許番号
US04552969

反応ノート

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