Sodium Hydroxide → 2-(2,4-Dimethoxyphenyl)ethan-1-amine

HRID 1583760

反応式

HRID 1583760 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[CH:11]=[CH:12][N+:13]([O-])=O.[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+]>O1CCCC1.CCOCC>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[CH2:11][CH2:12][NH2:13]

参加物

6

反応物 3

HCID 14798Sodium HydroxideHCID 2754052,4-Dimethoxy-1-(2-nitroethenyl)benzeneHCID 21226445Aluminium lithium hydride

生成物 1

HCID 4176042-(2,4-Dimethoxyphenyl)ethan-1-amine

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

The ethylene compound in 500 ml of tetrahydrofuran was added to 36.7 g of lithium aluminum hydride in 500 ml of ether. After a reflux period of 1.5 hours, the mixture was combined with 184 ml of lN sodium hydroxide solution. The resulting cake was separated by filtration and washed with 200 ml of hot tetrahydrofuran. The ethereal extracts and mother liquors were stripped. The residual oil was taken into chloroform, dried and stripped to give 94.9 g of 2,4-dimethoxyphenethylamine as an oil.

後処理

  1. customThe resulting cake was separated by filtration
  2. washwashed with 200 ml of hot tetrahydrofuran
  3. customdried

出典と根拠

ORDレコード
ord-806561b4111e483198c47d83a09b1c06
出典データセット
uspto-grants-1985_11
特許番号
US04554284

関連ノート

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