Toluene → N-[5-tert-Butyl-4-(hexadecyloxy)-2-hydroxyphenyl]acetamide

HRID 1583918ノート

反応式

HRID 1583918 の反応式
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])=[CH:7][C:6]=1[OH:28])(=[O:3])[CH3:2].[C:29]1([CH3:35])[CH:34]=CC=C[CH:30]=1.C=C(C)C>CCCCCC>[C:1]([NH:4][C:5]1[CH:10]=[C:9]([C:29]([CH3:35])([CH3:34])[CH3:30])[C:8]([O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])=[CH:7][C:6]=1[OH:28])(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 1140TolueneHCID 8255IsobutyleneHCID 13765207N-[4-(Hexadecyloxy)-2-hydroxyphenyl]acetamide

生成物 1

HCID 20257269N-[5-tert-Butyl-4-(hexadecyloxy)-2-hydroxyphenyl]acetamide

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

実験手順

A mixture of 30.0 g of 2-acetylamino-5-hexadecyloxyphenol obtained in Synthesis Example 3, 20.0 g of Amberlyst 15 (produced by Rohm & Haas, Co., U.S.A.) and 300 ml of toluene was stirred while heating at 80° to 90° C. during which isobutene was bubbled therethrough for 5 hours. The reaction solution was filtered to remove solids and the filtrate was condensed. On adding 350 ml of n-hexane to the residue, crystals precipitated. The crystals were collected by filtration. 23.5 g of 2-acetylamino-4-tert-butyl-5-hexadecyloxyphenol was obtained.

後処理

  1. customwas bubbled
  2. filtrationThe reaction solution was filtered
  3. customto remove solids
  4. customcondensed
  5. customprecipitated
  6. filtrationThe crystals were collected by filtration

出典と根拠

ORDレコード
ord-32d51b714aea4e5984c9af9dad9211f9
出典データセット
uspto-grants-1985_11
特許番号
US04555470

反応ノート

読み込み中…