N,N-Dimethylaniline → 6-Chloro-2-[(3-chloro-4-methoxyphenyl)amino]-3-nitrobenzoic acid

HRID 1584049

反応式

HRID 1584049 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[O:9][CH3:10])[NH2:5].Cl[C:12]1[C:20]([N+:21]([O-:23])=[O:22])=[CH:19][CH:18]=[C:17]([Cl:24])[C:13]=1[C:14]([OH:16])=[O:15].CN(C)C1C=CC=CC=1>C(Cl)(Cl)Cl>[Cl:24][C:17]1[C:13]([C:14]([OH:16])=[O:15])=[C:12]([NH:5][C:4]2[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:2]([Cl:1])[CH:3]=2)[C:20]([N+:21]([O-:23])=[O:22])=[CH:19][CH:18]=1

参加物

5

反応物 3

HCID 949N,N-DimethylanilineHCID 214413-Chloro-4-methoxyanilineHCID 3506232,6-Dichloro-3-nitrobenzoic acid

生成物 1

HCID 135883476-Chloro-2-[(3-chloro-4-methoxyphenyl)amino]-3-nitrobenzoic acid

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A mixture of 30 g of 3-chloro-4-methoxyaniline, 18.9 g of 2,6-dichloro-3-nitrobenzoic acid, and 150 ml N,N-dimethylaniline was heated at 100° under nitrogen for 24 hours. The reaction mixture was dissolved in chloroform and washed with dilute ammonium hydroxide. After the aqueous layer was washed with chloroform, it was acidified and the resulting orange solid was collected to provide 6-chloro-2[(3-chloro-4-methoxyphenyl)amino]-3-nitrobenzoic acid, mp 222°-228° C.

後処理

  1. temperaturewas heated at 100° under nitrogen for 24 hours
  2. washwashed with dilute ammonium hydroxide
  3. washAfter the aqueous layer was washed with chloroform, it
  4. customthe resulting orange solid was collected

出典と根拠

ORDレコード
ord-a7352c50bb6e4742ba8586532a9d2024
出典データセット
uspto-grants-1985_11
特許番号
US04555572

関連ノート

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