4-(1,1-Dimethylethoxycarbonyl)amino-3-methylphenoxyacetamide → 2-(4-Amino-3-methylphenoxy)acetamide
反応式
CC(C)(OC([NH:7][C:8]1[CH:18]=[CH:17][C:11]([O:12][CH2:13][C:14]([NH2:16])=[O:15])=[CH:10][C:9]=1[CH3:19])=O)C>FC(F)(F)C(O)=O>[NH2:7][C:8]1[CH:18]=[CH:17][C:11]([O:12][CH2:13][C:14]([NH2:16])=[O:15])=[CH:10][C:9]=1[CH3:19]参加物
3
反応条件
- 温度
- 0 °C
実験手順
To a 200 m1L round bottomed flask with a stirring bar and an argon inlet was added 4-(1,1-dimethylethoxycarbonyl)amino-3-methylphenoxyacetamide (4.91 g, 17.52 mmol) and trifluoroacetic acid (50 mL). This solution was stirred at 0° C. for 5 h. The trifluoroacetic acid was removed in vacuo and the residue was partitioned between EtOAc and aqueous NaHCO3 solution. The layers were separated and the organic phase was washed with brine, dried (MgSO4), filtered and concentrated in vacuo to give 1.60 g of 4-amino-3-methylphenoxy-acetamide as a white solid.