4-Bromodiphenyl Ether → 4-Phenoxythiophenol
反応式
C[S-:2].[Na+].[CH:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[CH:16]=[CH:15][C:14](Br)=[CH:13][CH:12]=2)=[CH:6][CH:5]=1.[OH-].[Na+]>CN(C)C=O>[O:10]([C:11]1[CH:16]=[CH:15][C:14]([SH:2])=[CH:13][CH:12]=1)[C:7]1[CH:8]=[CH:9][CH:4]=[CH:5][CH:6]=1参加物
5
実験手順
A solution of sodium thiomethoxide (25 g) and 4-bromodiphenyl ether (25 g) in N,N-dimethylformamide (DMF) (150 ml) was refluxed overnight. The mixture was cooled and added to dilute aqueous sodium hydroxide. The water layer was washed with ether to remove by-products and acidified with hydrochloric acid. The product, 4-(phenoxy)thiophenol, was extracted with ether, and the ether layer dried and evaporated to give 4-(phenoxy)thiophenol (19-20 g) as a red oil. This material can be used without further purification.
後処理
- temperatureThe mixture was cooled
- washThe water layer was washed with ether
- customto remove by-products
- extractionThe product, 4-(phenoxy)thiophenol, was extracted with ether
- dry with materialthe ether layer dried
- customevaporated
出典と根拠
- ORDレコード
- ord-a6aba2dfd74044c49c81ea8fa9aa4cb5
- 出典データセット
- uspto-grants-1999_08
- 特許番号
- US05932595
反応ノート
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