N-(tert-butoxy)-2-[1-(4-phenoxyphenylthio)cyclopent-1-yl]-acetamide → N-hydroxy-2-[1-(4-phenoxyphenylthio)-cyclopent-1-yl]-acetamide

HRID 1584397ノート

反応式

HRID 1584397 の反応式
C([O:5][NH:6][C:7](=[O:28])[CH2:8][C:9]1([S:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:17][CH:16]=2)[CH2:13][CH2:12][CH2:11][CH2:10]1)(C)(C)C>FC(F)(F)C(O)=O>[OH:5][NH:6][C:7](=[O:28])[CH2:8][C:9]1([S:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)=[CH:17][CH:16]=2)[CH2:13][CH2:12][CH2:11][CH2:10]1

参加物

3

反応物 1

HCID 21224113N-(tert-butoxy)-2-[1-(4-phenoxyphenylthio)cyclopent-1-yl]-acetamide

生成物 1

HCID 21224318N-hydroxy-2-[1-(4-phenoxyphenylthio)-cyclopent-1-yl]-acetamide

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

The N-tert-butoxy-2-[1-(4-phenoxyphenylthio)-cyclopent-1-yl]-acetamide was dissolved in trifluoroacetic acid (6 ml) and allowed to stand for 24 hours. The acid was evaporated off under reduced pressure and the product purified by preparative TLC, eluting with 6.5% methanol/methylene chloride gave N-hydroxy-2-[1-(4-phenoxyphenylthio)-cyclopent-1-yl]-acetamide (100 mg).

後処理

  1. customThe acid was evaporated off under reduced pressure
  2. customthe product purified by preparative TLC
  3. washeluting with 6.5% methanol/methylene chloride

出典と根拠

ORDレコード
ord-ff650d42c7dc4b5b89dc19df337cac31
出典データセット
uspto-grants-1999_08
特許番号
US05932595

反応ノート

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