Chlorotrimethylsilane → Methyl 2-(3-nitrophenyl)acetate

HRID 15844

反応式

HRID 15844 の反応式
[CH3:1][Si](Cl)(C)C.[N+:6]([C:9]1[CH:10]=[C:11]([CH2:15][C:16]([OH:18])=[O:17])[CH:12]=[CH:13][CH:14]=1)([O-:8])=[O:7]>CO>[N+:6]([C:9]1[CH:10]=[C:11]([CH2:15][C:16]([O:18][CH3:1])=[O:17])[CH:12]=[CH:13][CH:14]=1)([O-:8])=[O:7]

参加物

4

反応物 2

HCID 6397ChlorotrimethylsilaneHCID 158763-Nitrophenylacetic acid

生成物 1

HCID 526967Methyl 2-(3-nitrophenyl)acetate収率 100%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Trimethylsilyl chloride (5.6 mL, 2.0 equiv.) was added to a stirred solution of (3-nitrophenyl)acetic acid (4.0 g) in methanol (60 ml). The resulting solution was stirred at room temperature for 18 hours, then concentrated at reduced pressure and partitioned between DCM and aqueous sodium hydrogencarbonate solution. The organic phase was dried over sodium sulfate, filtered and concentrated under vacuum to give the title compound as a colourless liquid (4.2 g, 100%).

後処理

  1. concentrationconcentrated at reduced pressure
  2. custompartitioned between DCM and aqueous sodium hydrogencarbonate solution
  3. dry with materialThe organic phase was dried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under vacuum

出典と根拠

ORDレコード
ord-abfb52f871d248ef81b0d73cfbd63c99
出典データセット
uspto-grants-2010_06
特許番号
US07732600B2

関連ノート

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