Methanesulfonyl chloride → Fur-2-ylmethyl 2-methanesulfonylethyl ether
反応式
O[CH2:2][CH2:3][O:4][CH2:5][C:6]1[O:7][CH:8]=[CH:9][CH:10]=1.C(N(CC)C(C)C)(C)C.[CH3:20][S:21](Cl)(=[O:23])=[O:22]>ClCCl>[CH3:20][S:21]([CH2:2][CH2:3][O:4][CH2:5][C:6]1[O:7][CH:8]=[CH:9][CH:10]=1)(=[O:23])=[O:22]参加物
5
実験手順
Combine fur-2-ylmethyl 2-hydroxyethyl ether (10 mmol), and N,N-diisopropylethylamine (4.0 mL, 23 mmol), and dichloromethane (20 mL). Cool in an ice-bath. Add dropwise, methanesulfonyl chloride (1.0 mL, 13 mmol). After 1.5 hours, extract the reaction mixture with 1 M aqueous hydrochloric acid solution, saturated aqueous sodium bicarbonate solution, and saturated aqueous sodium chloride solution. Dry the organic layer over Na2SO4, filter, and evaporate in vacuo to obtain fur-2-ylmethyl 2-methanesulfonylethyl ether.
後処理
- temperatureCool in an ice-bath
- additionAdd dropwise
- extractionextract the reaction mixture with 1 M aqueous hydrochloric acid solution, saturated aqueous sodium bicarbonate solution, and saturated aqueous sodium chloride solution
- dry with materialDry the organic layer over Na2SO4
- filtrationfilter
- customevaporate in vacuo
出典と根拠
- ORDレコード
- ord-fa3ebdede7aa4ffebd39c1c38da4f227
- 出典データセット
- uspto-grants-1999_08
- 特許番号
- US05932571
反応ノート
読み込み中…