Hydrochloric Acid → 4-Amino-2,5-difluoro-3-difluoromethoxybenzoic acid
反応式
[NH2:1][C:2]1[C:12]([F:13])=[CH:11][C:5]([C:6]([O:8]CC)=[O:7])=[C:4]([F:14])[C:3]=1[O:15][CH:16]([F:18])[F:17].[OH-].[Na+].Cl>C(O)C>[NH2:1][C:2]1[C:12]([F:13])=[CH:11][C:5]([C:6]([OH:8])=[O:7])=[C:4]([F:14])[C:3]=1[O:15][CH:16]([F:17])[F:18]参加物
5
反応条件
- 温度
- 40 °C
実験手順
In 61 ml of ethanol was suspended 12.3 g of ethyl 4-amino-2,5-difluoro-3-difluoromethoxybenzoate, and 31 ml of 2N aqueous sodium hydroxide solution was added to the suspension, after which the resulting mixture was stirred at 40° C. for one hour. To the reaction mixture was added 35 ml of 2N hydrochloric acid and the precipitate formed was collected by filtration, to obtain 10.6 g of colorless, crystalline 4-amino-2,5-difluoro-3-difluoromethoxybenzoic acid.
後処理
- additionwas added to the suspension
- customthe precipitate formed
- filtrationwas collected by filtration
出典と根拠
- ORDレコード
- ord-e769fbc175f34164b82ab8818a084b6a
- 出典データセット
- uspto-grants-1999_08
- 特許番号
- US05935952
反応ノート
読み込み中…