Hydrazine → Ethyl 2-hydrazinyl-4-methylpyrimidine-5-carboxylate
反応式
Cl[C:2]1[N:7]=[C:6]([CH3:8])[C:5]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:4][N:3]=1.[NH2:14][NH2:15]>C1COCC1>[NH:14]([C:2]1[N:7]=[C:6]([CH3:8])[C:5]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:4][N:3]=1)[NH2:15]参加物
4
実験手順
The title compound was prepared as described in Example 18, but employing a solution of ethyl 2-chloro-4-methylpyrimidine-5-carboxylate (0.08 g, 0.39 mmol) and hydrazine (0.06 g, 2.0 mmol) in THF (7.8 mL) resulting in a 93% yield (0.07 g); 1H NMR (CDCl3) δ 8.86 (s, 1H), 6.64 (bs, 1H), 4.33 (q, 2H), 2.70 (s, 3H), 1.38 (t, 3H).
後処理
- customresulting in a 93% yield (0.07 g)
出典と根拠
- ORDレコード
- ord-181ae7272d814e54a91fa1597cb8b374
- 出典データセット
- uspto-grants-1999_08
- 特許番号
- US05935966
反応ノート
読み込み中…