Oxygen → (R)-Methyl 2-acetamidopropanoate
反応式
[C:1]([NH:4][C:5](=[CH2:10])[C:6]([O:8][CH3:9])=[O:7])(=[O:3])[CH3:2].O=O>CO>[CH3:9][O:8][C:6](=[O:7])[C@@H:5]([CH3:10])[NH:4][C:1](=[O:3])[CH3:2]参加物
4
実験手順
A solution of methyl 2-acetamidoacrylate (22 mg, 0.15 mmol) and the catalyst (I) (1 mg, 0.0015, 1 mol %) in degassed methanol (1 ml) was prepared under exclusion of oxygen in a GC-vial. The vial was placed in a 50 ml Parr reactor which was purged with hydrogen and charged to 3.41 MPa (500 psi). After hydrogenation of the mixture overnight, the solvent was evaporated to give the (R)-N-acetylalanine methyl ester (complete conversion, 62.8% ee).
後処理
- customwas purged with hydrogen
- additioncharged to 3.41 MPa (500 psi)
- customAfter hydrogenation of the mixture overnight, the solvent was evaporated
出典と根拠
- ORDレコード
- ord-71eb623e647f485ab24eeb75219c2a86
- 出典データセット
- uspto-grants-1999_08
- 特許番号
- US05936109
反応ノート
読み込み中…