Hydrochloric Acid → SULFONILAMIDE,N-(4-INDOLYL)
反応式
[NH:1]1[C:9]2[C:4](=[C:5]([NH:10][S:11]([C:14]3[CH:19]=[CH:18][C:17]([NH:20]C(=O)C)=[CH:16][CH:15]=3)(=[O:13])=[O:12])[CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.Cl>[OH-].[Na+]>[NH2:20][C:17]1[CH:18]=[CH:19][C:14]([S:11]([NH:10][C:5]2[CH:6]=[CH:7][CH:8]=[C:9]3[C:4]=2[CH:3]=[CH:2][NH:1]3)(=[O:13])=[O:12])=[CH:15][CH:16]=1参加物
4
実験手順
0.15 g (0.00045 mol) of N-[4-(1H-indol-4-ylsulfamoyl)-phenyl]-acetamide was dissolved in 4 ml of 1N NaOH and boiled at reflux for 1 hour. After cooling the mixture was adjusted to pH 6 with 0.1N HCl and the precipitate which separated was filtered off. The material on the suction filter was washed with copious water and dried. It was subsequently chromatographed on silica gel with ethyl acetate/hexane 1:1. There was obtained 0.085 g (66%) of 4-amino-N-(1H-indol-4-yl)-benzenesulfonamide as a white amorphous solid; m.p.: 215° C.