反応式
C[O:2][C:3]([C:5]1[O:6][C:7]([C:10]#[N:11])=[CH:8][CH:9]=1)=O.[BH4-].[Na+].[NH4+].[Cl-]>C(O)C>[OH:2][CH2:3][C:5]1[O:6][C:7]([C:10]#[N:11])=[CH:8][CH:9]=1参加物
5
実験手順
A solution of the ester from step 1 (0.098 g, 0.652 mmol), in ethanol (2.5 ml) at 0° C. was treated with sodium borohydride (0.11 g, 2.936 mmol) and the reaction was stirred for 2 hrs. Saturated NH4Cl solution (1 ml) was added and the aqueous extracted with diethylether. The combined extracts were dried (MgSO4) and evaporated in vacuo. The residue was chromatographed (silica gel, diethylether) to afford the title compound.
後処理
- extractionthe aqueous extracted with diethylether
- dry with materialThe combined extracts were dried (MgSO4)
- customevaporated in vacuo
- customThe residue was chromatographed (silica gel, diethylether)
出典と根拠
- ORDレコード
- ord-92585bef1193432a95ed990f1dd1fe62
- 出典データセット
- uspto-grants-1999_08
- 特許番号
- US05939439
関連ノート
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