Carbon tetrabromide → 4-Bromomethyl-2-(2,2,2-trifluoro-ethoxy)-benzonitrile

HRID 1585917ノート

反応式

HRID 1585917 の反応式
[F:1][C:2]([F:16])([F:15])[CH2:3][O:4][C:5]1[CH:12]=[C:11]([CH2:13]O)[CH:10]=[CH:9][C:6]=1[C:7]#[N:8].C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C(Br)(Br)(Br)[Br:37]>C1COCC1>[Br:37][CH2:13][C:11]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[C:5]([O:4][CH2:3][C:2]([F:16])([F:15])[F:1])[CH:12]=1

参加物

5

反応物 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 187796882-(2,2,2-Trifluoro-ethoxy)-4-hydroxymethyl-benzonitrile

生成物 1

HCID 187797974-Bromomethyl-2-(2,2,2-trifluoro-ethoxy)-benzonitrile

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

2-(2,2,2-Trifluoro-ethoxy)-4-hydroxymethyl-benzonitrile (1.4 g, 6.1 mmol) was dissolved in THF (31 ml) and treated with Ph3P (2.4 g, 9.15 mmol) followed by CBr4 (3 g, 9.15 mmol). The reaction mixture was stirred at room temp. for 2 hours. The solvent was removed in vacuo and the residue purified by flash chromatography (20% EtOAc/Hexane) to yield the desired product.

後処理

  1. customThe solvent was removed in vacuo
  2. customthe residue purified by flash chromatography (20% EtOAc/Hexane)

出典と根拠

ORDレコード
ord-8797ec7764d84703a8edb7b1d9f21b70
出典データセット
uspto-grants-1999_08
特許番号
US05939439

反応ノート

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