Carbon tetrabromide → 4-(Bromomethyl)benzene-1,2-dicarbonitrile

HRID 1585936ノート

反応式

HRID 1585936 の反応式
O[CH2:2][C:3]1[CH:4]=[C:5]([C:11]#[N:12])[C:6](=[CH:9][CH:10]=1)[C:7]#[N:8].C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C(Br)(Br)(Br)[Br:33]>C1COCC1>[Br:33][CH2:2][C:3]1[CH:4]=[C:5]([C:11]#[N:12])[C:6](=[CH:9][CH:10]=1)[C:7]#[N:8]

参加物

5

反応物 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 18779681HCID 18779681、化合物

生成物 1

HCID 187797764-(Bromomethyl)benzene-1,2-dicarbonitrile

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

4-Hydroxymethyl-phthalonitrile from step 2 (1.3 g, 8.2 mmol) was dissolved in THF (41 ml) and treated with Ph3P (3.2 g, 12.3 mmol) followed by CBr4 (4 g, 12.3 mmol). The reaction mixture was stirred at room temp. for 21 hours. The solvent was removed in vacuo and the residue purified by flash chromatography (15% EtOAc/Hexane) to yield the desired product. FAB MS: 222 m/z (M+ +H)

後処理

  1. customThe solvent was removed in vacuo
  2. customthe residue purified by flash chromatography (15% EtOAc/Hexane)

出典と根拠

ORDレコード
ord-54025b39475040fbb0c53cd9b00fe561
出典データセット
uspto-grants-1999_08
特許番号
US05939439

反応ノート

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