Carbon tetrabromide → 4-Bromomethyl-2-cyanobiphenyl
反応式
O[CH2:2][C:3]1[CH:4]=[C:5]([C:15]#[N:16])[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:7][CH:8]=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C(Br)(Br)(Br)[Br:37]>C1COCC1>[Br:37][CH2:2][C:3]1[CH:4]=[C:5]([C:15]#[N:16])[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:7][CH:8]=1参加物
5
実験手順
5-Hydroxymethyl-biphenyl-2-carbonitrile from step 3 (1.3 g, 6.2 mmol) was dissolved in THF (31 ml) and treated with Ph3P (2.4 g, 9.3 mmol) followed by CBr4 (3 g, 9.3 mmol). The reaction was mixture stirred at room temp. for 16 hours. The solvent was removed in vacuo and the residue was purified by flash chromatography (10% EtOAc/Hexane) to yield the desired product. FAB MS: m/z 272 (M+ +H)
後処理
- customThe solvent was removed in vacuo
- customthe residue was purified by flash chromatography (10% EtOAc/Hexane)
出典と根拠
- ORDレコード
- ord-1fb74cd68e7d46538d18a3ea2318b6cb
- 出典データセット
- uspto-grants-1999_08
- 特許番号
- US05939439
反応ノート
読み込み中…