4-Methoxyphenol → 4-(4-Methoxyphenoxy)benzaldehyde

HRID 1586091ノート

反応式

HRID 1586091 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1.Br[C:11]1[CH:18]=[CH:17][C:14]([CH:15]=[O:16])=[CH:13][CH:12]=1.C(=O)([O-])[O-].[K+].[K+]>N1C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][C:11]2[CH:18]=[CH:17][C:14]([CH:15]=[O:16])=[CH:13][CH:12]=2)=[CH:5][CH:4]=1

参加物

5

反応物 3

HCID 90154-MethoxyphenolHCID 11430Potassium CarbonateHCID 707414-Bromobenzaldehyde

生成物 1

HCID 104895194-(4-Methoxyphenoxy)benzaldehyde収率 85%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A mixture of 4-methoxyphenol (1.0 g, 0.00806 mol), 4-bromobenzaldehyde (1.49 g, 0.00805 mol), CuO (0.64 g, 0.00805 mol), potassium carbonate (1.11 g, 0.00803 mol) in pyridine (100 mL) was refluxed for 60 h. The reaction mixture was filtered into ice/water and the product was extracted with ethyl acetate. The organic layer was washed with water, dried (MgSO4), concentrated and chromatographed with CH2Cl2 to afford 1.56 g (85%) of 4-(4-methoxyphenoxy)benzaldehyde.

後処理

  1. temperaturewas refluxed for 60 h
  2. filtrationThe reaction mixture was filtered into ice/water
  3. extractionthe product was extracted with ethyl acetate
  4. washThe organic layer was washed with water
  5. dry with materialdried (MgSO4)
  6. concentrationconcentrated
  7. customchromatographed with CH2Cl2

出典と根拠

ORDレコード
ord-5241f8d49ba34ccbafa6ce360080a7f6
出典データセット
uspto-grants-1999_08
特許番号
US05942532

反応ノート

読み込み中…