Hydrochloric Acid → Betaxolol Hydrochloride

HRID 1586272

反応式

HRID 1586272 の反応式
[CH3:1][CH:2]([NH:4][CH2:5][CH:6]([OH:22])[CH2:7][O:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][CH2:16][O:17][CH2:18][CH:19]2[CH2:21][CH2:20]2)=[CH:13][CH:14]=1)[CH3:3].[ClH:23]>C1(C)C=CC=CC=1.C(O)(C)C>[CH3:3][CH:2]([NH:4][CH2:5][CH:6]([OH:22])[CH2:7][O:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][CH2:16][O:17][CH2:18][CH:19]2[CH2:21][CH2:20]2)=[CH:13][CH:14]=1)[CH3:1].[ClH:23]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 2369Betaxolol

生成物 1

HCID 107952Betaxolol Hydrochloride収率 99%

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒HCID 3776Isopropanol溶媒

実験手順

The oil obtained in Example 1 (179 grams) was dissolved in 400 mL of isopropylamine. After the reaction solution was refluxed for 2 days, the isopropylamine was distilled off and the residue was dissolved in 200 mL of toluene. The toluene was removed by vacuum distillation to give 222 grams of 1-{4-[2-(Cyclopropylmethoxy)ethyl]phenoxy}-3-isopropylamino-propane-2-ol (Betaxolol free base) which was used for the preparation of the hydrochloride salt without additional purification. The Betaxolol free base was dissolved in 300 mL of toluene containg 20 mL of isopropanol. A stream of hydrogen chloride gas was passed through the above solution at 0° C. until the reaction mixture pH was less than 3.0. The solvent was removed by vacuum distillation, and the residue was crystallized from 400 mL of acetone to give 102 grams (99% pure) of Betaxolol hydrochloride.

後処理

  1. customThe solvent was removed by vacuum distillation
  2. customthe residue was crystallized from 400 mL of acetone

出典と根拠

ORDレコード
ord-4bf49b3677574b9c970f95986f248891
出典データセット
uspto-grants-1999_08
特許番号
US05942633

関連ノート

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