N-Iodosuccinimide → HCID 178478182、化合物

HRID 1586358ノート

反応式

HRID 1586358 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:13]=[CH:12][NH:11][N:10]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1.C1C(=O)N([I:21])C(=O)C1>ClCCl>[I:21][C:13]1[C:9]([C:4]2[CH:3]=[C:2]([Cl:1])[CH:7]=[C:6]([Cl:8])[CH:5]=2)=[N:10][NH:11][CH:12]=1

参加物

4

反応物 2

HCID 120273N-IodosuccinimideHCID 178478180HCID 178478180、化合物

生成物 1

HCID 178478182HCID 178478182、化合物収率 59%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

2.13 g (0.01 mol) of 3-(3,5-dichlorophenyl)pyrazole are dissolved, at room temperature and with stirring, in 50 ml of dichloromethane. 2.5 g (0.011 mol) of n-iodosuccinimide are then added and stirring is then continued for 4 days. The reaction mixture is then concentrated, the solid obtained is washed with heptane and boiled in 100 ml of 1N sodium hydroxide. After cooling, the solid is filtered, washed with water and dried to give 2 g (yield 59%, melting point: 170° C.) of 4-iodo-3-(3,5-dichlorophenyl)pyrazole.

後処理

  1. concentrationThe reaction mixture is then concentrated
  2. customthe solid obtained
  3. washis washed with heptane
  4. temperatureAfter cooling
  5. filtrationthe solid is filtered
  6. washwashed with water
  7. customdried

出典と根拠

ORDレコード
ord-a6e693548f194d1cb81482a444275690
出典データセット
uspto-grants-1999_08
特許番号
US05945382

反応ノート

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