Chloride → HCID 45115680、化合物

HRID 1586535ノート

反応式

HRID 1586535 の反応式
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8].[Cl-]>CO>[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][C@H:2]1[C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8]

参加物

4

反応物 2

HCID 312ChlorideHCID 21217073Tert-butyl pyrazinecarboxylate

生成物 1

HCID 45115680HCID 45115680、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Analogously to Example 4, 0.52 g (2.85 mmol) of tert-butyl pyrazinecarboxylate (prepared according to Example 2), 25.3 mg (54 μmol) of bicyclo[2.2.1 ]hepta-2,5-dienerhodium(I) chloride dimer and 61.5 mg (113.3 μmol) of 1-[1(R)-(di-tert-butylphosphino)ethyl]-2(S)- (diphenylphosphino)ferrocene were hydrogenated for 20 hours in 10 ml of methanol at 70° C. and 50 bar. A conversion of 67 percent was determined by NMR. The ee value was determined by hydrolyzing the ester (see Example 8).

出典と根拠

ORDレコード
ord-e9db4f1f2d1d4136be49c4beea417404
出典データセット
uspto-grants-1999_08
特許番号
US05945534

反応ノート

読み込み中…