Glycine → HCID 19597249、化合物

HRID 1586550ノート

反応式

HRID 1586550 の反応式
[OH-].[Na+].Cl[C:4]1[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=[O:7].[NH2:14][CH2:15][C:16]([OH:18])=[O:17].C(=O)([O-])[O-].[K+].[K+]>O.C(=O)([O-])[O-].[Cu+2]>[C:16]([CH:15]=[N:14][C:4]1[C:5](=[CH:9][CH:10]=[C:11]([Cl:13])[CH:12]=1)[C:6]([OH:8])=[O:7])([OH:18])=[O:17]

参加物

7

反応物 4

HCID 750GlycineHCID 57872,4-Dichlorobenzoic AcidHCID 11430Potassium CarbonateHCID 14798Sodium Hydroxide

生成物 1

HCID 19597249HCID 19597249、化合物収率 90%

試薬・触媒・溶媒 2

HCID 14452Copper carbonate触媒HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

20 g (0.5 mol) of NaOH are dissolved in 100 ml of water, and 38.2 g (0.2 mol) of 2,4-dichlorobenzoic acid, 22.5 g (0.3 mol) of glycine and 1.4 g (6 mmol) of basic copper carbonate are added. The mixture is heated to 80° C., and 28 g (0.2 mol) of potassium carbonate are added. It is heated at 100° C. for 3 h. The filtrate after filtration with suction while hot is added to 100 ml of water and adjusted to pH 1-2 with hydrochloric acid. The product then precipitates and is filtered with suction and dried. 41 g (0.18 mol; 89%) of N-carboxymethylene-4-chloroanthranilic acid are obtained.

後処理

  1. temperatureIt is heated at 100° C. for 3 h
  2. filtrationThe filtrate after filtration with suction
  3. additionwhile hot is added to 100 ml of water
  4. customThe product then precipitates
  5. filtrationis filtered with suction
  6. customdried

出典と根拠

ORDレコード
ord-5b048905c5294dde8c467d7b1b7a02a3
出典データセット
uspto-grants-1999_08
特許番号
US05945556

反応ノート

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