Chloroacetyl chloride → 2-(2-Chloroacetamido)-3-methylbenzoic acid
反応式
[CH3:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:4]([C:5]([OH:7])=[O:6])[C:3]=1[NH2:11].[Cl:12][CH2:13][C:14](Cl)=[O:15]>C1C=CC=CC=1>[CH3:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:4]([C:5]([OH:7])=[O:6])[C:3]=1[NH:11][C:14](=[O:15])[CH2:13][Cl:12]参加物
4
実験手順
3-Methylanthranilic acid 10 g (0.07 mol) was dissolved in dried benzene 100 ml. To this solution, chloroacetylchloride 5.81 ml (0.07 mol) was added dropwise at room temperature and heated under reflux for two hours. After cooling, deposited crystals were collected by filtration and recrystallized from benzene-toluene to obtain 3-methyl-N(chloroacetyl)anthranilic acid 11.7 g (yield: 79%).
後処理
- temperatureheated
- temperatureunder reflux for two hours
- temperatureAfter cooling
- filtrationdeposited crystals were collected by filtration
- customrecrystallized from benzene-toluene
出典と根拠
- ORDレコード
- ord-2fd3153c55fa4a25989a38048270e672
- 出典データセット
- uspto-grants-1993_06
- 特許番号
- US05217961
反応ノート
読み込み中…