Sodium Carbonate → 2,3-Dihydrospiro(indene-1,4'-piperidine)

HRID 1587679ノート

反応式

HRID 1587679 の反応式
Cl.[NH:2]1[CH2:7][CH2:6][C:5]2([C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH2:9][CH2:8]2)[CH2:4][CH2:3]1.C(=O)([O-])[O-].[Na+].[Na+]>O>[NH:2]1[CH2:7][CH2:6][C:5]2([C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH2:9][CH2:8]2)[CH2:4][CH2:3]1

参加物

4

反応物 2

HCID 10340Sodium CarbonateHCID 225093272,3-Dihydrospiro[indene-1,4'-piperidine] hydrochloride

生成物 1

HCID 156376162,3-Dihydrospiro(indene-1,4'-piperidine)

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Spiro[indane-1,4'-piperidine]hydrochloride (0.4 g, 1.8 mmol) was dissolved in water (20 ml), and the solution made alkaline using solid sodium carbonate. The mixture was extracted with ethyl acetate (5×20 ml), and the organic layers combined and dried (MgSO4). The solvent was removed in vacuo to give spiro[indane-1,4'-piperidine] as a clear oil, which was used without further purification.

後処理

  1. extractionThe mixture was extracted with ethyl acetate (5×20 ml)
  2. dry with materialdried (MgSO4)
  3. customThe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-7776102a157b4bbf89ddc33a0f5d7f25
出典データセット
uspto-grants-1993_06
特許番号
US05219860

反応ノート

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