m-Chloroperbenzoic acid → 6-butoxy-alpha-picoline N-oxide
反応式
[CH2:1]([O:5][C:6]1[N:11]=[C:10]([CH3:12])[CH:9]=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH3:4].ClC1C=CC=C(C(OO)=[O:21])C=1>C(OCC)C>[CH2:1]([O:5][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]([CH3:12])[N+:11]=1[O-:21])[CH2:2][CH2:3][CH3:4]参加物
4
実験手順
To a solution of 19.0 g (0.12 mol) of 6-butoxy-α-picoline dissolved in 250 ml of diethyl ether was portionwise added 23.8 g (0.14 mol) of m-chloroperbenzoic acid under ice-cooling. After standing under ice-cooling for one hour, the mixture was further left to stand at room temperature for several days. The reaction mixture was extracted with water and then adjusted to pH=11 with an addition of sodium carbonate. After extraction with chloroform, the extract was concentrated under a reduced pressure to give 11.2 g of the desired product.
後処理
- temperaturecooling
- temperaturecooling for one hour
- waitthe mixture was further left
- waitto stand at room temperature for several days
- extractionThe reaction mixture was extracted with water
- additionadjusted to pH=11 with an addition of sodium carbonate
- extractionAfter extraction with chloroform
- concentrationthe extract was concentrated under a reduced pressure
出典と根拠
- ORDレコード
- ord-ecf1ec186948484f845f8d0849ebd3b1
- 出典データセット
- uspto-grants-1993_06
- 特許番号
- US05219847
反応ノート
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